RiteMED Amoxicillin Adverse Reactions

As with other penicillins, it may be expected that untoward reactions will be related to sensitivity phenomena. They are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and cephalosporins and in those with a history of allergy, asthma, hay fever or urticaria.
The following adverse reactions have been reported with the use of amoxicillin: Dermatologic/Hypersensitivity Reactions: Anaphylaxis (usually associated with the parenteral dosage form), serum sickness-like reactions (urticaria or skin rash accompanied by arthritis, arthralgia, myalgia, and frequently fever); severe allergic reactions including angioedema; exanthema, acute and generalized exanthematous pustulosis (AGEP), bullous and exfoliative dermatitis, erythematous maculopapular rashes, erythema multiforme, hypersensitivity vasculitis, mucocutaneous/oral and vaginal candidiasis, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis.
GI: Nausea, vomiting, diarrhea, black "hairy" tongue, CDAD and colitis (during or following discontinuance of amoxicillin); hemorrhagic colitis; acute, transient enterocolitis with severe abdominal pain and bloody diarrhea, but without evidence of CDAD and colitis; glossitis, stomatitis, epigastric distress, gastritis, flatulence, soft stools, loss of appetite/anorexia, enanthemas/sore mouth or tongue, dry mouth, taste disturbances.
Nervous System: Agitation, anxiety, behavioral changes, confusion, convulsions (at extremely high doses), dizziness, reversible hyperactivity, hyperkinesia, insomnia.
When penicillin reaches a high concentration in the CSF, neurotoxic symptoms consisting of myoclonia, convulsive seizures and depressed consciousness may occur. Unless drug administration is discontinued or its dosage reduced, the syndrome may progress to coma and death.
Hemic and Lymphatic System: Anemia, including hemolytic anemia; agranulocytosis, abnormal platelet aggregation, eosinophilia, leukopenia, neutropenia, prolongation of bleeding time, prothrombin time and activated partial thromboplastin time (APTT); thrombocytopenia, thrombocytopenic purpura.
Hepatic: A moderate rise in aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT); transient increases in serum alkaline phosphatase and lactate dehydrogenase levels; hepatic dysfunction including cholestatic jaundice, hepatic cholestasis and acute cytolytic hepatitis.
Renal: Acute interstitial nephritis, crystalluria.
Other Adverse Effects: Tooth discoloration (brown, yellow, or gray staining) mostly in pediatric patients. In most cases, discoloration was reduced or eliminated with brushing or dental cleaning.